Angiogenesis is of great importance in implant dentistry and plays an important role in the osseointegration process. It is the mechanism by which new blood vessels develop from a pre-existing vasculature. A presentation with 3D images by German clinicians Maximilian Ackermann and Andreas Pabst from the University of Mainz provides fascinating details from the microcosm of the human body.

The human body contains about 60.000 miles of blood vessels (which is about 6 times the distance between Switzerland and Australia!). Blood vessel architecture can adapt to the different human tissues and organs and variegate within different physiological and pathological structures.

In this presentation,  Maximilian Ackermann MD and Andreas Pabst DMD from the Institute of Functional and Clinical Anatomy at the University Medical Center of the Johannes Gutenberg-University Mainz in Germany illustrate different physiological and pathological blood vessel architectures, which were replicated by Microvascular Corrosion Casting and visualized by Scanning Electron Microscopy (SEM) and Synchrotron X-ray tomographic microscopy (SRXTM).

With appropriate 3D glasses you can observe the 3D SEM and SRXTM images, which are highlighted by the respective “3D” symbol. Three examples from the presentation are displayed below, as well as a short video animation.

Maximilian Ackermann and Andreas Pabst: Imaging the vasculature – 3D insights into anatomy
Maximilian Ackermann, MD, Johannes Gutenberg-University Mainz, Germany

Maximilian Ackermann

Johannes Gutenberg-University Mainz, Germany

Dr. Maximilian Ackermann leads the Angiogenesis and Vascular Imaging Group at the Institute of Functional and Clinical Anatomy, University Medical Center of the Johannes Gutenberg-University Mainz in Germany. His group is focusing on angiogenesis in tumor growth, inflammation, fibrosis, and wound healing as well as on clinical anatomy.

Dr. Ackermann received his M.D. from the University of Mainz, Germany where he did his post-doctoral work in human anatomy. He also was trained at the University of Amsterdam. In a NIH-project with the Harvard Medical School, he investigates the adaptive processes involved in lung regeneration und fibrosis with a focus on microvascular anatomy and patterns of angiogenesis. He serves as medical and strategy consultant to the international management consultancy Roland Berger Strategy Consultants.

Dr. Ackermann is advisory board member of The Angiogenesis Foundation, an US- based nonprofit organization dedicated to improving global health through medicines, lifestyle, and dietary interventions based on angiogenesis, the process of new blood vessel growth.

Andreas Pabst, DMD

Andreas Pabst

Johannes Gutenberg-University Mainz, Germany

After graduating from high school in 2003 and military service, I completed dental and medical school at the University Medical Center in Mainz, Germany, from 2004 to 2015.

In 2011, I finished my doctoral thesis in dentistry in cell cultures at the Department of Oral- and Maxillofacial Surgery at the University Medical Center Mainz. In 2015, I started as training assistant at the Department of Oral- and Maxillofacial Surgery at the General Armed Forces Hospital in Koblenz, Germany.

My research focuses on Bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ), the development and enhancement of dental biomaterials and tissue engineering, different pathways of angiogenesis and blood vessel development as well as 3D imaging techniques in medical and dental research.