A lecture by David L. Cochran
Enamel matrix proteins have been clinically used for more than 2 decades and have been documented by vast clinical and preclinical research. Despite the broad biologic potential of enamel matrix proteins to stimulate various cell and tissue types into regenerative and tissue forming patterns, the potential of this component class has been so far only fully explored for the successful treatment of periodontal indications. Recent advances in the research on enamel matrix proteins as a mixture and as partial fractions of the mixture, show that besides inducing periodontal regeneration, enamel matrix proteins stimulate important processes for the formation, maturation and, regeneration of bone, such as the stimulation of osteoblasts and stem cells and the promotion of angiogenesis. With these properties in mind enamel matrix proteins can per se be classified as promising candidates to promote bone growth and bone maturation as part of clinical bone augmentation procedures in periodontology and, importantly in implantology.
This presentation introduces Straumann® Osteogain as a new biologic solution that has been developed and optimized for the mixing with bone graft materials and collagen substrates to stimulate bone formation as part of regenerative bone augmentation procedures. It introduces the product concept and rationale, its components and its biological properties to stimulate various physiological activities that are clinically relevant for various bone augmentation procedures.