A lecture by David L. Cochran

Aims

Enamel matrix proteins have been clinically used for more than 2 decades and have been documented by vast clinical and preclinical research. Despite the broad biologic potential of enamel matrix proteins to stimulate various cell and tissue types into regenerative and tissue forming patterns, the potential of this component class has been so far only fully explored for the successful treatment of periodontal indications. Recent advances in the research on enamel matrix proteins as a mixture and as partial fractions of the mixture, show that besides inducing periodontal regeneration, enamel matrix proteins stimulate important processes for the formation, maturation and, regeneration of bone, such as the stimulation of osteoblasts and stem cells and the promotion of angiogenesis. With these properties in mind enamel matrix proteins can per se be classified as promising candidates to promote bone growth and bone maturation as part of clinical bone augmentation procedures in periodontology and, importantly in implantology.

Objectives

This presentation introduces Straumann® Osteogain as a new biologic solution that has been developed and optimized for the mixing with bone graft materials and collagen substrates to stimulate bone formation as part of regenerative bone augmentation procedures. It introduces the product concept and rationale, its components and its biological properties to stimulate various physiological activities that are clinically relevant for various bone augmentation procedures.

David L. Cochran is a graduate of the University of Virginia and received his D.D.S., M.S. and Ph.D. in Biochemistry from the Medical College of Virginia (MCV). He was trained in Periodontology at the Harvard School of Dental Medicine where he also obtained a second Master‘s degree. He recently received an Honorary Doctorate from the University of Bern in Switzerland. Dr. Cochran is currently Professor and Chairman of the Department of Periodontics at The University of Texas Health Science Center at San Antonio, Dental School. Prior to his appointment at San Antonio, Dr. Cochran was Director of Postgraduate Periodontics at MCV. Dr. Cochran is a member of many professional dental organizations and is a Diplomate of the American Board of Periodontology. He is a fellow of the American College of Dentistry and the International College of Dentistry. Dr. Cochran has published numerous scientific articles and abstracts on various periodontal, biochemistry, and implant topics. He has received awards for his research work at both the national and international levels. Dr. Cochran is an active basic science and clinical researcher who has received funding from both the NIH-NIDCR and private industry.