In the following case, periodontal regenerative surgery with amelogenins (Emdogain®) produced complete filling of two adjacent vertical, deep and non-contained defects in the lower jaw. Moreover, the results were well maintained in the long term (6 years), as demonstrated clinically and radiologically. The periodontal regenerative treatment changed the prognosis of the lower first molar in a young patient, avoiding extraction and subsequent implant placement. The strict regimen of post-surgical control visits was critical for the successful long-term maintenance of the regenerative results.


Straumann® Emdogain® (used alone or in combination with bone graft) is arguably the material of choice to treat periodontal defects. Adding Emdogain® to an open flap debridement surgical procedure has demonstrated to yield significantly better clinical results than the procedure alone . Adding Emdogain® to the procedure has also been shown to significantly reduce post-surgical pain and swelling, as well as improve wound healing .

    • 20 years on the market
    • 2 million patients treated*
    • Over 1000 scientific publications***
    • Over 600 clinical publications
    • Extremely well tolerated**

*based on number of syringes sold globally
**based on a global post-surgical complication rate of less than 0.002%
*** based on pubmed search for Emdogain or “enamel matrix derivative”



A systemically healthy 33-year-old patient was diagnosed with localized aggressive periodontitis. A pre-operative x-ray (Fig.1) revealed an intra-bony defect in the distal aspect of tooth #46 and on the mesial aspect of tooth #45. Following the initial preparation, a residual 10 mm periodontal pocket was evident distal to tooth #46 and a 7 mm periodontal pocket mesial to tooth #45 (Figs. 2-3).


After causal therapy, the patient showed a good standard of supragingival plaque control (FMPS and FMBS<15%), and regenerative periodontal surgery with Emdogain® was scheduled.


Following local anesthesia, an envelope-type flap extending from distal #43 to mesial #47 was raised. The supracrestal soft tissue above the angular defects was preserved with the amplified papilla preservation technique between #47 and #46 and with the simplified papilla preservation technique between #45 and #44 (Figs. 4-5). The flap was elevated in a split-full-split approach. The surgical papillae were elevated split thickness, while the central portion of the flap was elevated full thickness until the bony defects were completely exposed. The lingual flap, together with the interdental supracrestal soft tissues, was raised full thickness. The flap elevation was followed by debridement: both bony defects were degranulated, and the root surfaces were planed with ultrasonic and manual instruments. The infrabony defect on #46 was classified as a two-wall defect in the most coronal portion (missing vestibular wall), becoming a three-wall defect in the apical portion. The infrabony defect on #45 was classified as one-wall defect in the most coronal area while, in the apical area, a three-wall defect was evident (Figs. 6-7). The root surfaces were conditioned with EDTA gel 24% for two minutes to remove the smear layer produced by the root planing. After rinsing with saline solution, Emdogain® was applied on the exposed root surface and in the defects (Figs. 8-9).The anatomical papillae between #43 and #44 and between #45 and #4.6 were de-epithelialized, and the buccal flap was moved coronally in order to suture the surgical papilla to the connective tissue of the anatomical papilla with single interrupted sutures. The interdental soft tissues preserved in the area of the infrabony defects (#44-#45 and #46-#47) were sutured by first intention with single interrupted Vicryl 6-0 sutures (Figs. 10-11). The patient was instructed not to brush the treated area. Plaque control was performed with chlorhexidine solution 0.12% three times daily for 15 days. Systemic antibiotic therapy (amoxicillin 1 g twice daily for 7 days) together with anti-inflammatory therapy (ibuprofen 600 mg twice daily for 2 days and subsequently as needed) were prescribed. The sutures were removed after 15 days (Figs. 12-13).


Dr. Martina Stefanini

Periodontologist and researcher (with Prof.Giovanni Zucchelli at the University of Bologny, Italy, currently in a Research Fellow position). Level II Master in Periodontology from the University of Siena (Italy). PhD in Medical Sciences from the University of Bologna. Teaching professor at the postgraduate program in Periodontology at the San Raffaele University in Milano, Italy and the Level II Master in Soft Tissue management at the University of Bologna. Active member of the Italian Society of Periodontology. Scientific author and speaker on national and international level.